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Showing 1–2 of 2 results
Advanced filters: Author: Melody Riaud Clear advanced filters

  • There is a lack of effective therapies for patients with non-V600E BRAF mutant cancer. Here, the authors report limited response in a phase II trial investigating the combination of binimetinib (MEK inhibitor) and encorafenib (BRAF inhibitor) for the treatment of non-V600E BRAF mutant cancer and subsequently investigate resistance mechanisms and combination therapeutic strategies in patient-derived models.

    • April A. N. Rose
    • Jennifer Maxwell
    • Anna Spreafico
    ResearchOpen Access
    Nature Communications
    P: 1-19

  • Although hyperactivation of BRAF has been well-established to drive tumour progression and drug resistance, the role of CRAF in cancer is becoming increasingly relevant. Here, Riaud et al. summarize the various oncogenic roles of CRAF and the potential for CRAF-targeted therapies to improve the clinical outcome for RAF1 altered tumours.

    • Melody Riaud
    • Jennifer Maxwell
    • April A. N. Rose
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 105-122