VISA/MAVS is the central adaptor in antiviral innate immunity, yet the assembly of VISA signalosome is unclear. This study reveals that PWWP3A competes with TRAF6 for binding to VISA, impeding the recruitment of TBK1 and subsequent IRF3 activation, which prevents excessive immune responses.
- Mengling Shi
- Cong Wang
- Caoqi Lei