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Showing 1–7 of 7 results

Advanced filters: Author: Mengna Zhu Clear advanced filters

Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment

This study elucidates the structural mechanism of HEP-50768, a novel MRGPRX4 inverse agonist, and demonstrates its potent anti-itch efficacy and favorable safety in preclinical models, positioning it as a promising therapeutic for chronic pruritus.

Jun Yang
Ruichao Shen
Xiaoguang Lei
Research09 Apr 2026
Nature Chemical Biology

P: 1-11
Deciphering phenylalanine-derived salicylic acid biosynthesis in plants

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

Yukang Wang
Shuyan Song
Ronghui Pan
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 208-217
LEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer

Lin Huang
Mengna Zhu
Man Xiao
ResearchOpen Access10 Sept 2025
Oncogene

Volume: 44, P: 4130-4144
SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice

Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. Here, the authors show that SGK1 drives hippocampal demyelination and DACD via regulating NDRG1 phosphorylation.

Ziying Jiang
Bin Liu
Qingqing Yin
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-18
CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer

Si Sun
Lin Huang
Jing Cai
ResearchOpen Access26 Mar 2026
Cell Death & Disease

Volume: 17, P: 1-15
Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting

Sensory detection of prey triggers hunting actions in predators. Zhao et al. show that the zona incerta integrates prey-related multisensory signals and induces a motivational drive to guide prey detection and promote predatory attack.

Zheng-dong Zhao
Zongming Chen
Wei L. Shen
Research24 May 2019
Nature Neuroscience

Volume: 22, P: 921-932
Identification of immune cells and circulating inflammatory factors associated with neurodevelopmental disorders by bidirectional Mendelian randomization and mediation analysis

Zhiyue Liu
Lihong Wang
Aihua Cao
ResearchOpen Access14 Apr 2025
Scientific Reports

Volume: 15, P: 1-16