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Showing 1–3 of 3 results
Advanced filters: Author: Mengqiu Dang Clear advanced filters

  • Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent transformation independently of the MLL complex.

    • Gongwei Wu
    • Mengqiu Yuan
    • Ping Gao
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • In this study, the authors found that interferon-γ mediates the protective effects of soluble receptor for advanced glycation end-product (SRAGE) on myocardial ischemia/reperfusion (MI/R) injuries in heart, which might be associated with the increasing expression of proteasome β5i. In addition, the increased β5i in cardiomyocytes promoted the p53 degradation which contributed to the anti-apoptosis effects of sRAGE in MI/R injuries.

    • Mengqiu Dang
    • Xiangjun Zeng
    • Caixia Guo
    Research
    Laboratory Investigation
    Volume: 99, P: 358-370