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Showing 1–4 of 4 results
Advanced filters: Author: Merav Socolovsky Clear advanced filters

  • Single-cell transcriptomics, fate assays and a computational theory enable prediction of cell fates during haematopoiesis, discovery of regulators of erythropoiesis and reveal coupling between the erythroid, basophil and mast cell fates.

    • Betsabeh Khoramian Tusi
    • Samuel L. Wolock
    • Merav Socolovsky
    Research
    Nature
    Volume: 555, P: 54-60

  • Two new studies suggest a crucial role for macrophages in boosting the number of red blood cells produced in vivo during stress, with translational implications for disease states such as β-thalassemia and polycythemia vera (pages 429–436 and 437–445).

    • Merav Socolovsky
    News & Views
    Nature Medicine
    Volume: 19, P: 399-401

  • Maturing erythroblasts become smaller with every cell division. Here, the authors show that Epo stimulation promotes cell division and also generates larger red cells, and that this occurs in mouse and human cells, suggesting that red cell size could be a diagnostic marker for hypoxic stress.

    • Daniel Hidalgo
    • Jacob Bejder
    • Merav Socolovsky
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.

    • A. Marieke Oudelaar
    • Robert A. Beagrie
    • Jim R. Hughes
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12