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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Liver metastases reduce clinical and preclinical immune-checkpoint inhibitor efficacy through hepatic siphoning of circulating activated CD8⁺ T cells, but therapeutic benefit can be improved by combining immunotherapy with liver-directed radiotherapy.

Jiali Yu
Michael D. Green
Weiping Zou
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 152-164

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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

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