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Agent-based modeling of cellular dynamics in adoptive cell therapy

ABMACT, an agent-based model of adoptive cell therapy, recapitulated cellular dynamics in two cancer preclinical models and showed that enhancing immune cell proliferation, cytotoxicity, and serial killing capacity is critical for optimal efficacy.

Yujia Wang
Stefano Casarin
Ken Chen
ResearchOpen Access11 Feb 2026
Communications Biology

P: 1-20
Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux

Metabolic reprogramming is a common indicator of the tumour microenvironment. Here the authors develop the METAflux framework to predict metabolic fluxes from single cell RNA-seq data.

Yuefan Huang
Vakul Mohanty
Ken Chen
ResearchOpen Access12 Aug 2023
Nature Communications

Volume: 14, P: 1-16
AI-powered Immune Cell Knowledge Graph (ICKG) with granular immune contexts enables immune program interpretation

Shan He
Yukun Tan
Ken Chen
ResearchOpen Access27 Jan 2026
npj Artificial Intelligence

Volume: 2, P: 1-12
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Hind Rafei
Rafet Basar
Katayoun Rezvani
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 1076-1086
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19⁺ B cell tumors: a phase 1/2 trial

In the final report of a phase 1/2 trial evaluating allogeneic CD19-specific CAR-NK cells armored with IL-15 in patients with CD19⁺ hematologic malignancies, the therapy was shown to be safe and efficacious with distinct cord blood features associated with response.

David Marin
Ye Li
Katayoun Rezvani
ResearchOpen Access18 Jan 2024
Nature Medicine

Volume: 30, P: 772-784
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation suppressor genes (PSG). Here, the authors develop an approach to systematically identify them, and reveal a PSG module involved in fatty acid synthesis and tumour suppression in acute myeloid leukemia cell lines.

W. Frank Lenoir
Micaela Morgado
Traver Hart
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-15
Expression of BCL-2 and Laminin in Rectosigmoid Hirschsprung Disease: Correlations with Hirschsprung−Associated Enterocolitis

Merve Dede
Fatih Celik
Irfan Kiristioglu
ResearchOpen Access14 Apr 2025
Pediatric Research

P: 1-8

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Agent-based modeling of cellular dynamics in adoptive cell therapy

Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux

AI-powered Immune Cell Knowledge Graph (ICKG) with granular immune contexts enables immune program interpretation

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells

Expression of BCL-2 and Laminin in Rectosigmoid Hirschsprung Disease: Correlations with Hirschsprung−Associated Enterocolitis

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Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19⁺ B cell tumors: a phase 1/2 trial