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Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.

Burak Ozkan
Mitzy Rios de Anda
Abdenour Soufi
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-26
Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

The complexity of epithelial cell states in the fibrotic niche in the context of chronic kidney disease remains incompletely understood. Here the authors integrate snRNA and ATAC-seq with high-plex single-cell molecular imaging to generate a spatially-revolved multiomic atlas of human kidney disease.

Maximilian Reck
David P. Baird
Bryan R. Conway
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-23
B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors

Induced pluripotent stem cell (iPSC) reprogramming is inherently inefficient. Here the authors identify 24 reprogramming roadblock genes through a CRISPR/Cas9-mediated genome-wide knockout screen including a KRAB-ZFP Zfp266, knockout of which consistently enhances murine iPSC generation.

Daniel F. Kaemena
Masahito Yoshihara
Keisuke Kaji
ResearchOpen Access30 Jan 2023
Nature Communications

Volume: 14, P: 1-16

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Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors

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