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Ringer’s lactate administered at 15 °C leads to a greater and more prolonged increase in blood pressure compared to 37 °C

Peter Biesenbach
Michaela Bitten Mølmer
Mikkel Brabrand
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression

Jin et al. identified PKN1 as the kinase responsible for histone phosphorylation-mediated FOS/FOSB induction and vessel inflammation in regions of disturbed blood flow, highlighting an additional regulation layer for atherosclerotic plaque development.

Young-June Jin
Guozheng Liang
Stefan Offermanns
ResearchOpen Access08 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 180-196
Endocardial HDAC3 is required for myocardial trabeculation

Lack of trabeculation compromises heart structure and function. How myocardial trabeculation is regulated by nonmyocytes is poorly understood. Researchers found that histone deacetylase 3 in the developing endocardial cells guides myocardial trabeculation by inducing growth signals.

Jihyun Jang
Mette Bentsen
Deqiang Li
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-12
The homeobox transcription factor DUXBL controls exit from totipotency

The transcription factor double homeobox protein (DUX) induces a totipotency-specific regulatory program, including the upregulation of DUXBL. DUXBL subsequently accesses DUX-bound regions and interacts with TRIM24 and TRIM33, thus contributing to totipotency exit.

Maria Vega-Sendino
Felipe F. Lüttmann
Sergio Ruiz
Research20 Mar 2024
Nature Genetics

Volume: 56, P: 697-709
ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation

Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development datasets.

Mette Bentsen
Philipp Goymann
Mario Looso
ResearchOpen Access26 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Scanpro is a tool for robust proportion analysis of single-cell resolution data

Yousef Alayoubi
Mette Bentsen
Mario Looso
ResearchOpen Access06 Jul 2024
Scientific Reports

Volume: 14, P: 1-12
Uncovering uncharacterized binding of transcription factors from ATAC-seq footprinting data

Hendrik Schultheis
Mette Bentsen
Mario Looso
ResearchOpen Access23 Apr 2024
Scientific Reports

Volume: 14, P: 1-13

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Ringer’s lactate administered at 15 °C leads to a greater and more prolonged increase in blood pressure compared to 37 °C

Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression

Endocardial HDAC3 is required for myocardial trabeculation

The homeobox transcription factor DUXBL controls exit from totipotency

ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation

Scanpro is a tool for robust proportion analysis of single-cell resolution data

Uncovering uncharacterized binding of transcription factors from ATAC-seq footprinting data

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