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A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

MicroRNAs regulate brain development and aging. Here, authors show that a spatio-temporal atlas of 15 mouse brain regions reveals sex- and region-specific microRNA patterns, including age-related microglial miR-155-5p increase targeting mTOR.

Annika Engel
Viktoria Wagner
Andreas Keller
ResearchOpen Access17 May 2025
Nature Communications

Volume: 16, P: 1-17
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Sophia M. Shi
Ryan J. Suh
Tony Wyss-Coray
ResearchOpen Access26 Feb 2025
Nature

Volume: 639, P: 985-994
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis

Hematopoietic cell transplantation (HCT) may be a promising therapy for treatment-refractory multiple sclerosis (MS). Mader et al. Describe beneficial effects of autologous HCT in a mouse model of MS and identify a myeloid transcriptional signature associated with neuroprotection.

Marius Marc-Daniel Mader
Alan Napole
Marius Wernig
Research21 Mar 2024
Nature Neuroscience

Volume: 27, P: 901-912