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Showing 1–7 of 7 results
Advanced filters: Author: Michael A. Trakselis Clear advanced filters

  • Clamp proteins that encircle DNA and then recruit enzymes are one of nature's ways of making catalysis on DNA processive. Here, a clamp protein is equipped with a synthetic catalyst that sequence-specifically oxidizes DNA. The resulting biohybrid catalyst shows processive behaviour, which is visualized by atomic force microscopy.

    • Stijn F. M. van Dongen
    • Joost Clerx
    • Roeland J. M. Nolte
    Research
    Nature Chemistry
    Volume: 5, P: 945-951

  • The MCM8/9 helicase has been implicated in DNA recombination processes with mutations in these genes causative for infertility and cancer. Here, the authors show that MCM8/9 aids normal fork progression and also stabilizes persistently stalled forks, acting upstream of RAD51 and BRCA1.

    • Wezley C. Griffin
    • David R. McKinzey
    • Michael A. Trakselis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Single-molecule studies reveal that a ring-like enzyme that encircles and 'slides' along one strand of duplex DNA, separating it from the other strand, overcomes molecular barriers in its path by transiently opening its ring. See Article p.205

    • Michael A. Trakselis
    • Brian W. Graham
    News & Views
    Nature
    Volume: 492, P: 195-197

  • Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions and recruit replicative helicases to form a pre-replication complex independent of the DNA sequence.

    • Sai Li
    • Michael R. Wasserman
    • Shixin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Among the numerous molecular machines involved in the process of DNA replication are the ring-shaped sliding clamp and the clamp loader. Intriguing structural details of their interaction are now revealed.

    • Michael A. Trakselis
    • Stephen D. Bell
    News & Views
    Nature
    Volume: 429, P: 708-709

  • Structures of the clamp loader–clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

    • Zhihao Zhuang
    • Michelle M Spiering
    • Stephen J Benkovic
    News & Views
    Nature Structural & Molecular Biology
    Volume: 11, P: 580-581