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Nature Chemical Biology (2)

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Advanced filters: Author: Michael Arciprete Clear advanced filters

Systematic identification of biomarker-driven drug combinations to overcome resistance

Identification of genes associated with resistance to hundreds of cancer therapeutics enabled the discovery of the serine hydrolases MGLL and CES1 as modifiers of sensitivity to GSK-J4 via direct enzymatic modification.

Matthew G. Rees
Lisa Brenan
Cory M. Johannessen
Research24 Mar 2022
Nature Chemical Biology

Volume: 18, P: 615-624
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Inhibitors of the post-proline-cleaving serine proteases DPP8 and DPP9 trigger a lytic form of programmed cell death called pyroptosis by activating pro-caspase-1 without autoproteolysis.

Marian C Okondo
Darren C Johnson
Daniel A Bachovchin
Research07 Nov 2016
Nature Chemical Biology

Volume: 13, P: 46-53

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Systematic identification of biomarker-driven drug combinations to overcome resistance

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

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