Development of eye-specific segregation and binocularity in the superior colliculus, dorsal lateral geniculate nucleus and primary visual cortex is partly attributed to the timing of spontaneous retinal waves, in which bursts of activity are thought to act through a Hebbian learning rule to guide circuit refinement. This study uses the latest optogenetic tools to provide definitive evidence for the binocular activity timing rule—and the specific temporal features of activity—in dictating binocularity development in the mouse visual system.
- Jiayi Zhang
- James B Ackman
- Michael C Crair
