Giuseppe Narzisi et al. present Lancet, a genome-wide somatic variant caller using localized colored de Bruijn graphs. Comparisons using real and simulated data show that Lancet has improved accuracy for single nucleotide variants and indels compared to widely used methods MuTect2, LoFreq and Strelka2.
- Giuseppe Narzisi
- André Corvelo
- Michael C. Zody
