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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides a resource for potential classifications and targets.

Shideh Mirhadi
Shirley Tam
Ming-Sound Tsao
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers

Nhu-An Pham
Nikolina Radulovich
Ming-Sound Tsao
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-12
Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target for non-epithelioid mesothelioma.

Meilin Chan
Licun Wu
Marc de Perrot
ResearchOpen Access26 Jul 2021
Communications Biology

Volume: 4, P: 1-12
Minimalist approaches to cancer tissue-of-origin classification by DNA methylation

Daniel Xia
Alberto Jose Leon
Kenneth Aldape
Research15 May 2020
Modern Pathology

Volume: 33, P: 1874-1888

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