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Showing 1–10 of 10 results
Advanced filters: Author: Michael Dussiot Clear advanced filters

  • Michael Dussiot et al. show that an activin receptor IIA ligand trap ameliorates anemia in a mouse model of β-thalassemia by blocking the deleterious effects of GDF11. Mechanistically, GDF11 inactivation reversed ineffective erythropoiesis by promoting terminal erythroblast differentiation and by inducing apoptosis of immature erythroblasts. Also in this issue, Rajasekhar Suragani et al. show related findings using a modified activin receptor IIB ligand trap.

    • Michael Dussiot
    • Thiago T Maciel
    • Ivan C Moura
    Research
    Nature Medicine
    Volume: 20, P: 398-407

  • Séverine Coulon et al. identify a new mechanism regulating red blood cell production through transferrin receptor engagement. By binding this receptor on erythroblasts, the polymeric form of immunoglobin A1 (pIgA1) or iron-loaded transferrin acts in conjunction with erythropoietin to promote erythroblast maturation. Administration of either pIgA1 or iron-loaded transferrin accelerated recovery from anemia in mice, suggesting that these findings may have therapeutic implications.

    • Séverine Coulon
    • Michaël Dussiot
    • Ivan C Moura
    Research
    Nature Medicine
    Volume: 17, P: 1456-1465

  • The heat-shock protein Hsp70 can regulate the development of red blood cells, or erythropoiesis. Hsp70 interacts with GATA-1 and protects it from cleavage, thus controlling the differentiation of erythrocytes by its presence in the nucleus.

    • Jean-Antoine Ribeil
    • Yael Zermati
    • Olivier Hermine
    Research
    Nature
    Volume: 445, P: 102-105

  • Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophages, CSF-1R localizes to TSS, co-localizes with H3K4me3, and interacts with ELK and YY1.

    • Laura Bencheikh
    • M’Boyba Khadija Diop
    • Nathalie Droin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safety and tolerability of one identified compound in a phase I clinical trial.

    • Mario Carucci
    • Julien Duez
    • Pierre Buffet
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • In a lupus environment, basophils accumulate in secondary lymphoid organs where they affect pathogenesis by stimulating autoantibody production. Here the authors show this accumulation is driven by PGD2-induced CXCR4 surface expression and trafficking of basophils.

    • Christophe Pellefigues
    • Barbara Dema
    • Nicolas Charles
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling.

    • Mathieu P. Rodero
    • Alessandra Tesser
    • Yanick J. Crow
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • In human β-thalassaemiaerythroblasts, HSP70 is sequestered in the cytoplasm by the excess of free α-globin chains and can no longer protect the master transcriptional factor of erythropoiesis GATA-1 from caspase-3 cleavage; transduction of a nuclear-targeted HSP70 or a caspase-3 uncleavable GATA-1 mutant restored maturation of erythropoiesis.

    • Jean-Benoît Arlet
    • Jean-Antoine Ribeil
    • Geneviève Courtois
    Research
    Nature
    Volume: 514, P: 242-246