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Showing 1–11 of 11 results
Advanced filters: Author: Michael Frieden Clear advanced filters

  • A qualitative analysis of two decades of policy documents from 200 countries and interviews with 46 key informants found that adoption of policies to promote physical activity has increased since 2004, but implementation remains weak because physical activity is still a low, albeit gradually increasing, political priority in most countries.

    • Andrea Ramírez Varela
    • Adrian Bauman
    • Michael Pratt
    ResearchOpen Access
    Nature Health
    Volume: 1, P: 338-354

  • Cardiovascular disease is the world's leading cause of death, with a disproportionate burden in low-income and middle-income countries. The Resolve initiative — eliminating artificial trans fats, reducing dietary sodium, and improving treatment of elevated blood pressure — is a substantial step in the right direction, but more combined efforts will be required.

    • Rajesh Vedanthan
    • Valentin Fuster
    News & Views
    Nature Reviews Cardiology
    Volume: 15, P: 7-8

  • Changes in lipidome profiles, as reflected by improvements in dietary fat quality from saturated to unsaturated fats, were associated with reduced cardiometabolic disease risk, and high-risk populations with unhealthy lipidome profiles would most benefit from an olive oil-rich Mediterranean diet.

    • Fabian Eichelmann
    • Marcela Prada
    • Clemens Wittenbecher
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2867-2877

  • The carboxy terminus of human UDP-α-d-glucose-6-dehydrogenase is structurally disordered, but has sequence-independent effects on the conformation of the enzyme and binding of an allosteric inhibitor, suggesting a reason for the persistence of intrinsically disordered peptide segments in the proteome.

    • Nicholas D. Keul
    • Krishnadev Oruganty
    • Zachary A. Wood
    Research
    Nature
    Volume: 563, P: 584-588

  • Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the treatment of α-amanitin antibody conjugates.

    • Yujing Li
    • Yunhua Liu
    • Xiongbin Lu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The 17q23 amplicon containing the WIP1 oncogene is frequently amplified in HER2+ breast cancer. Here they find MIR21 to be present in WIP1-containing amplicons, and report nanoparticle based co-delivery of WIP1 and miR-21 inhibitors to be effective in trastuzumab-resistant HER2+ breast cancer.

    • Yunhua Liu
    • Jiangsheng Xu
    • Xinna Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation with RNA.

    • Jasmine Cubuk
    • Jhullian J. Alston
    • Alex S. Holehouse
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17