Nature Search

The uncertainty inherent to DEM simulations of interlocking particles

Lukas Maier
Michael Mitterlindner
Stefan Radl
ResearchOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1-18
3D scans, angles of repose and bulk densities of 108 bulk material heaps

Michael Rackl
Florian E. Grötsch
ResearchOpen Access29 May 2018
Scientific Data

Volume: 5, P: 1-8
Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Here, Tisza, Dekker, and colleagues perform large scale analysis of genome methylation in the gut commensal and pathogen, Bacteroides fragilis group, revealing immense methyl motif diversity and evidence of widespread methyltransferase exchange among phages.

Michael J. Tisza
Derek D. N. Smith
John P. Dekker
ResearchOpen Access10 Jul 2023
Nature Communications

Volume: 14, P: 1-15
Cost-effectiveness of the ReDIRECT/counterweight-plus weight management programme to alleviate symptoms of long COVID

A recent randomised controlled trial demonstrated effectiveness of a remote diet intervention to reduce long covid symptoms in people living with overweight/obesity in the UK. Here, the authors assess the cost-effectiveness of this intervention from the health system and societal perspectives.

Heather L. Fraser
Laura Haag
Emma McIntosh
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Hydrothermal weakening and slope instability at Vulcano (Italy) analyzed using drones and in-situ strength measurements

At La Fossa cone, Vulcano, Italy, alteration intensity, when categorized by color, correlates with rock weakening and past mass wasting events, as determined by drone mapping and in-situ strength surveys.

Benjamin F. De Jarnatt
Thomas R. Walter
Antonino Fabio Pisciotta
ResearchOpen Access04 Dec 2025
Communications Earth & Environment

Volume: 7, P: 1-17
Hydrothermal alteration of andesitic lava domes can lead to explosive volcanic behaviour

The permeability of a dome exerts a control on the outgassing efficiency of the underlying magma. The authors investigate the role of hydrothermal alteration on this process in the laboratory and use these data to model whether the overpressures generated are capable of promoting explosive behaviour.

Michael J. Heap
Valentin R. Troll
Thomas R. Walter
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-10
Seasonal changes of mélange thickness coincide with Greenland calving dynamics

Mélange is reported to be thinner in summer during glacier terminus retreat and thicker in winter during terminus advance. A discrete element model is created to estimate the forces that mélange exerts to buttress Greenland glaciers.

Yue Meng
Ching-Yao Lai
Kavinda Nissanka
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Structural variation in the pangenome of wild and domesticated barley

A pangenome analysis of 76 wild and domesticated barley accessions in combination with short-read sequence data of 1,315 barley genotypes indicates that allelic diversity at structurally complex loci may have helped crop plants to adapt to agricultural ecosystems.

Murukarthick Jayakodi
Qiongxian Lu
Nils Stein
ResearchOpen Access13 Nov 2024
Nature

Volume: 636, P: 654-662
Molecular basis of crossreactivity and the limits of antibody–antigen complementarity

Jairo H. Arevalo
Michael J. Taussig
Ian A. Wilson
Research28 Oct 1993
Nature

Volume: 365, P: 859-863
Phreatic eruptions at Whakaari Volcano driven by hydrothermal mineralisation and magmatic gas input

Phreatic eruptions at Whakaari volcano are influenced by subsurface pressurisation magnitudes and timescales, which are significantly influenced by hydrothermal mineralisation and magmatic gas input rates, according to 3-dimensional numerical modelling of volcanic hydrothermal systems.

Sophie C. Pearson-Grant
Michael J. Heap
Adrian E. Croucher
ResearchOpen Access16 Dec 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Pradeep Natarajan
Akhil Pampana
Gina M. Peloso
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Measuring the past

Michael Vickers
Books & Arts26 Apr 2001
Nature

Volume: 410, P: 1030
HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Graham Heap, Tariq Ahmad and colleagues show that common variants in the HLA-DQA1–HLA-DRB1 region confer susceptibility to thiopurine-induced pancreatitis in individuals undergoing treatment for inflammatory bowel diseases. These findings could help identify patients at risk of developing this serious adverse reaction to thiopurine therapy.

Graham A Heap
Michael N Weedon
Tariq Ahmad
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1131-1134
LinkedSV for detection of mosaic structural variants from linked-read exome and genome sequencing data

Compared to single nucleotide variants and short indels, structural variants (SVs) are often more challenging to detect using high-throughput sequencing based methods. Here, the authors develop LinkedSV, a computational tool for SV detection using linked-read exome and genome sequencing data.

Li Fang
Charlly Kao
Kai Wang
ResearchOpen Access06 Dec 2019
Nature Communications

Volume: 10, P: 1-15
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

Erik L. Bao
Satish K. Nandakumar
Vijay G. Sankaran
Research14 Oct 2020
Nature

Volume: 586, P: 769-775
Detecting and annotating genetic variations using the HugeSeq pipeline

Hugo Y K Lam
Cuiping Pan
Michael Snyder
Correspondence07 Mar 2012
Nature Biotechnology

Volume: 30, P: 226-229
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX

Mikkel Schubert
Luca Ermini
Ludovic Orlando
Protocols10 Apr 2014
Nature Protocols

Volume: 9, P: 1056-1082
A generative diffusion-based AI-model to scrutinise the microstructural degradation of isothermally aged Cu-SAC305 interfaces

Charlotte Cui
Fereshteh Falah Chamasemani
Roland Brunner
ResearchOpen Access17 May 2025
npj Materials Degradation

Volume: 9, P: 1-16
Shocking degeneration

Mammalian small heat-shock proteins are suspected to have a role in neuromuscular function. Two new studies provide evidence for the association of mutations in two of these proteins, HSP22 and HSP27, with human neuromuscular disorders.

Rainer Benndorf
Michael J Welsh
News & Views01 Jun 2004
Nature Genetics

Volume: 36, P: 547-548
Local geology controlled the feasibility of vitrifying Iron Age buildings

Fabian B. Wadsworth
Michael J. Heap
Donald B. Dingwell
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Digital framework for georeferenced multiplatform surveillance of banana wilt using human in the loop AI and YOLO foundation models

Juan Jose Mora
Guy Blomme
Michael Gomez Selvaraj
ResearchOpen Access28 Jan 2025
Scientific Reports

Volume: 15, P: 1-30
A problem in theory

Muthukrishna & Henrich argue that solving the replication crisis in psychology partly requires well-specified, overarching theoretical frameworks. They outline how dual inheritance theory provides one such example that could be adopted by the field.

Michael Muthukrishna
Joseph Henrich
Reviews11 Feb 2019
Nature Human Behaviour

Volume: 3, P: 221-229
Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models

Michael Sloth Trabjerg
Anne Skøttrup Mørkholt
John Dirk Vestergaard Nieland
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-19
Hidden mechanical weaknesses within lava domes provided by buried high-porosity hydrothermal alteration zones

Herlan Darmawan
Valentin R. Troll
Daniel Müller
ResearchOpen Access25 Feb 2022
Scientific Reports

Volume: 12, P: 1-14
Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell–Renal-Cell-Carcinoma: Proof-of-Concept Study

Qingbo Yin
Sheng-Che Hung
Dinggang Shen
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-11

Search

The uncertainty inherent to DEM simulations of interlocking particles

3D scans, angles of repose and bulk densities of 108 bulk material heaps

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Cost-effectiveness of the ReDIRECT/counterweight-plus weight management programme to alleviate symptoms of long COVID

Hydrothermal weakening and slope instability at Vulcano (Italy) analyzed using drones and in-situ strength measurements

Hydrothermal alteration of andesitic lava domes can lead to explosive volcanic behaviour

Seasonal changes of mélange thickness coincide with Greenland calving dynamics

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Structural variation in the pangenome of wild and domesticated barley

Molecular basis of crossreactivity and the limits of antibody–antigen complementarity

Phreatic eruptions at Whakaari Volcano driven by hydrothermal mineralisation and magmatic gas input

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Measuring the past

HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

LinkedSV for detection of mosaic structural variants from linked-read exome and genome sequencing data

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Detecting and annotating genetic variations using the HugeSeq pipeline

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX

A generative diffusion-based AI-model to scrutinise the microstructural degradation of isothermally aged Cu-SAC305 interfaces

Shocking degeneration

Local geology controlled the feasibility of vitrifying Iron Age buildings

Digital framework for georeferenced multiplatform surveillance of banana wilt using human in the loop AI and YOLO foundation models

A problem in theory

Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models

Hidden mechanical weaknesses within lava domes provided by buried high-porosity hydrothermal alteration zones

Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell–Renal-Cell-Carcinoma: Proof-of-Concept Study

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