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Showing 1–3 of 3 results
Advanced filters: Author: Michael J. Parnham Clear advanced filters

  • Chronic pain presents a major health burden, affecting more than 20% of adults worldwide, but currently available analgesics lack efficacy and/or are associated with severe adverse effects. Here, Ellen Niederberger and colleagues discuss epigenetic modulation as a new opportunity in pain-relief therapy, and consider the future challenges for the clinical development of these drugs.

    • Ellen Niederberger
    • Eduard Resch
    • Gerd Geisslinger
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 434-447

  • Academic research has a key role in identifying new drug targets, but to lead to new drugs this research must progress to testing drug candidates in clinical trials, which are typically conducted by industry. This Perspective presents a framework to support academic scientists and funders in prioritizing target assessment activities and in defining a critical path to reach scientific goals as well as goals related to licensing, partnering with industry or initiating clinical trials.

    • Christoph H. Emmerich
    • Lorena Martinez Gamboa
    • Michael J. Parnham
    Reviews
    Nature Reviews Drug Discovery
    Volume: 20, P: 64-81