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Local translation in microglial processes is required for efficient phagocytosis

Vasek et al. demonstrate that distal processes of microglia locally translate specific mRNAs including those related to immunity and phagocytosis. They then show that local protein synthesis is necessary for microglial process-initiated phagocytosis.

Michael J. Vasek
Shayna M. Mueller
Joseph D. Dougherty
Research05 Jun 2023
Nature Neuroscience

Volume: 26, P: 1185-1195
Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1

Klein and colleagues show, in a mouse model of West Nile virus–induced cognitive dysfunction, that neurogenesis is impaired by production of IL-1 from pro-inflammatory astrocytes.

Charise Garber
Michael J. Vasek
Robyn S. Klein
Research01 Jan 2018
Nature Immunology

Volume: 19, P: 151-161
Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

Quaking RNA binding protein (QKI) is known for its role in oligodendrocyte maturation. Here, the authors define the QKI targets in the mouse brain and show that loss of QKI disrupts the expression of cell maturation-associated genes in astrocytes in vivo.

Kristina Sakers
Yating Liu
Joseph D. Dougherty
ResearchOpen Access09 Mar 2021
Nature Communications

Volume: 12, P: 1-14
A complement–microglial axis drives synapse loss during virus-induced memory impairment

People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with the virus experience a loss in hippocampal presynaptic terminals, which can be reversed by disrupting complement or microglia in mice.

Michael J. Vasek
Charise Garber
Robyn S. Klein
Research22 Jun 2016
Nature

Volume: 534, P: 538-543

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Local translation in microglial processes is required for efficient phagocytosis

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1

Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

A complement–microglial axis drives synapse loss during virus-induced memory impairment

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