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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1^-/y mice

Kornfeld-Sylla et al reveal how alpha brainwaves are altered in children and adults with Fragile X Syndrome (FXS) and find parallel changes in alpha-like rhythms in juvenile and adult FXS model mice, showing their use for testing potential therapies.

Sara S. Kornfeld-Sylla
Cigdem Gelegen
Mark F. Bear
ResearchOpen Access09 Feb 2026
Nature Communications

Volume: 17, P: 1-22

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1^-/y mice