Understanding how complexes, such as Mediator, that act at diverse promoters interact with gene-specific transcription factors is key to understanding transcriptional regulation. The solution structure of Med25 (Arc92) is now presented and its interaction with helices on the VP16 activator elucidated. The Med25 interface is found to be conserved, but VP16 is revealed to be more diverse in its interaction with different interactors.
- Erika Vojnic
- André Mourão
- Patrick Cramer
