Hypotonic fluid administration has been the standard of care for maintenance fluid therapy in acutely ill children, but this approach is associated with hospital-acquired hyponatraemia and hyponatraemic encephalopathy. New findings demonstrate that isotonic maintenance fluids are safe and effective in preventing hospital-acquired hyponatraemia in children, whereas a 0.45% NaCl solution is not.
- Michael L. Moritz
- Juan C. Ayus
