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Showing 1–6 of 6 results
Advanced filters: Author: Michael N. Wosczyna Clear advanced filters

  • Aging leads to progressive loss of effective tissue regeneration, which has been linked to the accumulation of senescent cells. Here, the authors use machine learning to identify a stable nuclear morphometric phenotype that detects senescent cells across tissues and age, enabling their quantification and mapping in diverse environments.

    • Sahil A. Mapkar
    • Sarah A. Bliss
    • Michael N. Wosczyna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

    • Hongqing Du
    • Chung-Hsuan Shih
    • Brian J. Feldman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

    • Róbert Pálovics
    • Andreas Keller
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 603, P: 309-314

  • Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

    • Nicholas Schaum
    • Benoit Lehallier
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 583, P: 596-602