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Showing 1–5 of 5 results
Advanced filters: Author: Michael P. Hutchens Clear advanced filters

  • The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.

    • Homan Kang
    • Murui Han
    • Jonghan Kim
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.

    • Vijay Saxena
    • Hongyu Gao
    • Andrew L. Schwaderer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • This article highlights results from a comprehensive study of the performance of clinical trial sites, which could help companies understand the underlying drivers of success.

    • Brendan Smith
    • Linda Martin
    • Michael S. Ringel
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 17, P: 389-390

  • This Review summarizes the state of the art of acute kidney injury model development, focusing on the translatability of discoveries using human kidney organoid, zebrafish, rodent and large animal models. The authors recommend a multidisciplinary approach to optimize the development of effective therapies for acute kidney injury.

    • Neil A. Hukriede
    • Danielle E. Soranno
    • Mark P. de Caestecker
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 277-293