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Showing 1–5 of 5 results
Advanced filters: Author: Michael S. Parmacek Clear advanced filters

  • Endothelial–vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.

    • Daniel J. Rader
    • Michael S. Parmacek
    News & Views
    Nature Cell Biology
    Volume: 14, P: 233-235

  • Edward Morrisey and colleagues show that mice lacking the transcription factor Gata6 in the lung epithelium have an increased number of bronchioalveolar stem cells during development and in the context of lung regeneration. Additional evidence suggests that a Gata6-Wnt pathway regulates the balance of stem cell expansion and epithelial differentiation in the lung.

    • Yuzhen Zhang
    • Ashley M Goss
    • Edward E Morrisey
    Research
    Nature Genetics
    Volume: 40, P: 862-870

  • A hallmark of stem cells is an open chromatin largely devoid of heterochromatin, but which molecules are required to maintain it is unknown, as well as whether an open chromatin is necessary for the differentiation potential of stem cells. Here, the chromatin remodelling factor Chd1 is shown to be required to maintain the open chromatin state of pluripotent mouse embryonic stem cells and to be essential for the pluripotency of these cells.

    • Alexandre Gaspar-Maia
    • Adi Alajem
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 460, P: 863-868