Nature Search

A two-stage mechanism for escape of Na and K from Io

Michael E. Summers
Yuk L. Yung
Peter K. Haff
Research01 Aug 1983
Nature

Volume: 304, P: 710-712
Transfer of methylene groups promoted by metal complexation

Michael Gozin
Michael Aizenberg
David Milstein
Research07 Jul 1994
Nature

Volume: 370, P: 42-44
Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats

In rats, functional ultrasound imaging reveals that blocking opioid receptors modulates the effects of subanesthetic ketamine on neural activity in males but not in females, with parallel changes in ketamine’s effects on brain structure and behavior.

Tommaso Di Ianni
Sedona N. Ewbank
Raag D. Airan
ResearchOpen Access30 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components

Soha A. Hassan
Michael Stumpe
Jürgen A. Ripperger
ResearchOpen Access29 Dec 2025
Scientific Reports

Volume: 16, P: 1-13
All-optical voltage interrogation for probing synaptic plasticity in vivo

Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

Jacques Carolan
Michelle A. Land
Michael Häusser
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4⁺8⁺ thymocytes

Pawel Kisielow
Horst Blüthmann
Harald von Boehmer
Research23 Jun 1988
Nature

Volume: 333, P: 742-746
Relative comparisons of call parameters enable auditory grouping in frogs

Male túngara frogs produce overlapping mating calls, which poses a challenge for the female frog to group and assign multiple auditory signals to the correct source. Farris and Ryan shows that, like humans, the female frogs compare and group signals using the smallest relative difference in call parameters.

Hamilton E. Farris
Michael J. Ryan
Research02 Aug 2011
Nature Communications

Volume: 2, P: 1-8
Papers and patents are becoming less disruptive over time

A decline in disruptive science and technology over time is reported, representing a substantive shift in science and technology, which is attributed in part to the reliance on a narrower set of existing knowledge.

Michael Park
Erin Leahey
Russell J. Funk
Research04 Jan 2023
Nature

Volume: 613, P: 138-144
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

A method termed ac⁴C-seq is introduced for the transcriptome-wide mapping of the RNA modification N⁴-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.

Aldema Sas-Chen
Justin M. Thomas
Schraga Schwartz
Research17 Jun 2020
Nature

Volume: 583, P: 638-643
Semi-automated assembly of high-quality diploid human reference genomes

Which combination of current genome sequencing and assembly approaches results in high-quality, complete diploid genome assemblies is determined.

Erich D. Jarvis
Giulio Formenti
Karen H. Miga
ResearchOpen Access19 Oct 2022
Nature

Volume: 611, P: 519-531
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A massive phytoplankton bloom induced by an ecosystem-scale iron fertilization experiment in the equatorial Pacific Ocean

Kenneth H. Coale
Kenneth S. Johnson
Raphael Kudela
Research10 Oct 1996
Nature

Volume: 383, P: 495-501
Chemical and biological evolution of a nucleotide-binding protein

Michael G. Rossmann
Dino Moras
Kenneth W. Olsen
Research19 Jul 1974
Nature

Volume: 250, P: 194-199
Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site

HIV relies on the RRE RNA interaction with Rev protein for nuclear export of viral mRNAs. The structure of the high-affinity Rev binding site in RRE in two conformations suggests a mechanism for initial Rev binding and oligomerization onto RRE.

Jerricho Tipo
Keerthi Gottipati
Kyung H. Choi
ResearchOpen Access17 May 2024
Nature Communications

Volume: 15, P: 1-13
Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis

The authors present a molecular approach and a software suite for high-throughput sequencing and characterization of microbial tRNA transcripts, which provide unique physiological insights into complex environmental microbes.

Michael H. Schwartz
Haipeng Wang
A. Murat Eren
ResearchOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-13
Comparison of classical and autogenous systems of regulation in inducible operons

Michael A. Savageau
Research13 Dec 1974
Nature

Volume: 252, P: 546-549
Calculation of electrostatic potentials in an enzyme active site

Michael K. Gilson
Barry H. Honig
Research05 Nov 1987
Nature

Volume: 330, P: 84-86
Charcot–Marie–Tooth neuropathy type 1B is associated with mutations of the myelin P₀ gene

Kiyoshi Hayasaka
Masato Himoro
Phillip F. Chance
Research01 Sept 1993
Nature Genetics

Volume: 5, P: 31-34
Non-canonical resource allocation in heterotrophically growing Thermoanaerobacter kivui

Proteome allocation to anabolic and catabolic functions is significantly regulated by growth rate in the model bacterium Escherichia coli. By contrast, this article shows that proteome allocation is only partially controlled by growth rate, and metabolic rates are primarily controlled post-translationally, in the thermophilic acetogen Thermoanaerobacter kivui.

Franziska Maria Mueller
Albert Leopold Müller
Alfred Michael Spormann
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution

Cytosine base modifications 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) are present in mammalian DNA. Reduced bisulfite sequencing is now developed for quantitatively sequencing 5fC at single-base resolution. This method is then applied with oxidative bisulfite sequencing to gain a map of 5mC, 5hmC and 5fC in mouse embryonic stem cells.

Michael J. Booth
Giovanni Marsico
Shankar Balasubramanian
Research23 Mar 2014
Nature Chemistry

Volume: 6, P: 435-440
Aquatic sources and sinks for nitrous oxide

James W. Elkins
Steven C. Wofsy
Warren A. Kaplan
Research19 Oct 1978
Nature

Volume: 275, P: 602-606
Detailed Molecular Model for Transfer Ribonucleic Acid

MICHAEL LEVITT
Research22 Nov 1969
Nature

Volume: 224, P: 759-763
Mutation detection by electrocatalysis at DNA-modified electrodes

Elizabeth M. Boon
Donato M. Ceres
Jacqueline K. Barton
Research01 Oct 2000
Nature Biotechnology

Volume: 18, P: 1096-1100
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

Mark D. Iafrati
Richard H. Karas
Michael E. Mendelsohn
Research01 May 1997
Nature Medicine

Volume: 3, P: 545-548
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA

Florian C Oberstrass
Albert Lee
Frédéric H-T Allain
Research22 Jan 2006
Nature Structural & Molecular Biology

Volume: 13, P: 160-167
Search for a Human Breast Cancer Virus

DAN H. MOORE
JESSE CHARNEY
A. B. VAIDYA
Research26 Feb 1971
Nature

Volume: 229, P: 611-615
Structure of pyruvate kinase and similarities with other enzymes: possible implications for protein taxonomy and evolution

Michael Levine
Hilary Muirhead
David I. Stuart
Research16 Feb 1978
Nature

Volume: 271, P: 626-630
YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial

As presented at the ESMO Congress 2025: In patients with locally advanced or metastatic solid tumours, including mesothelioma, treatment with a first-in-class inhibitor of the Hippo−YAP−TEAD pathway was safe and led to encouraging clinical response rates in patients with mesothelioma.

Timothy A. Yap
David J. Kwiatkowski
Hedy L. Kindler
Research19 Oct 2025
Nature Medicine

Volume: 31, P: 4281-4290
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Structure of southern bean mosaic virus at 2.8 Å resolution

Celerino Abad-Zapatero
Sherin S. Abdel-Meguid
Tomitake Tsukihara
Research03 Jul 1980
Nature

Volume: 286, P: 33-39
A brain-wide map of neural activity during complex behaviour

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Leenoy Meshulam
Dora Angelaki
Ilana B. Witten
ResearchOpen Access03 Sept 2025
Nature

Volume: 645, P: 177-191
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Bernard Binétruy
Tod Smeal
Michael Karin
Research09 May 1991
Nature

Volume: 351, P: 122-127
A narrow hybrid zone between two Western Australian frog species Ranidella insignifera and R. pseudinsignifera: the fitness of hybrids

C Michael Bull
Research01 Jun 1979
Heredity

Volume: 42, P: 381-389
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y

Michael J. Mitchell
Diane R. Woods
Colin E. Bishop
Research08 Oct 1992
Nature

Volume: 359, P: 528-531
Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution

The conformational heterogeneity of RNA molecules makes their structure determination by X-ray crystallography and NMR challenging. Here the authors show that RNA structures can be solved by cryo-EM and present the structures of a 40 kDa SAM-IV riboswitch in the apo form and bound to its ligand S-adenosylmethionine.

Kaiming Zhang
Shanshan Li
Wah Chiu
ResearchOpen Access03 Dec 2019
Nature Communications

Volume: 10, P: 1-6
Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

DNA polymerase δ (Pol δ) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol δ catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-Å resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.

Michael K Swan
Robert E Johnson
Aneel K Aggarwal
Research30 Aug 2009
Nature Structural & Molecular Biology

Volume: 16, P: 979-986
A mutational signature in gastric cancer suggests therapeutic strategies

Cancer genome analysis has demonstrated that some breast and ovarian tumours show reduced homologous recombination, a feature that can be therapeutically exploited. Here, Alexandrov et al.search for this mutational signature in 36 different cancer types and find that some gastric tumours also harbour this mutational spectrum.

Ludmil B. Alexandrov
Serena Nik-Zainal
Michael R Stratton
ResearchOpen Access29 Oct 2015
Nature Communications

Volume: 6, P: 1-7
Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function

150 years ago, guanidine was found to affect muscle function via unknown mechanisms. Here, Kavita et al. provide evidence that guanine-sensing RNAs are present in many eukaryotic transcripts relevant to Ca2+ signaling and neuromuscular function.

Kumari Kavita
Aya Narunsky
Ronald R. Breaker
ResearchOpen Access09 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Alexandre Pellan Cheng
Adam J. Widman
Dan A. Landau
Research11 Apr 2025
Nature Methods

Volume: 22, P: 973-981
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
An integrated approach for finding overlooked genes in yeast

Anuj Kumar
Paul M. Harrison
Michael Snyder
Research01 Jan 2002
Nature Biotechnology

Volume: 20, P: 58-63
Light–matter interaction in a microcavity-controlled graphene transistor

Graphene's remarkable properties make it ideal for optoelectronic devices, and its two-dimensional nature enables its integration with photonic structures. By combining a graphene transistor with a planar microcavity, Engelet al. control the spectrum of the photocurrent and the light emitted by the device.

Michael Engel
Mathias Steiner
Ralph Krupke
ResearchOpen Access19 Jun 2012
Nature Communications

Volume: 3, P: 1-6
Tau-targeting antisense oligonucleotide MAPT_Rx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial

Evaluation of a tau-targeting antisense oligonucleotide in a phase 1 trial of patients with mild AD found it was well tolerated and resulted in a sustained reduction of tau protein levels.

Catherine J. Mummery
Anne Börjesson-Hanson
Roger M. Lane
ResearchOpen Access24 Apr 2023
Nature Medicine

Volume: 29, P: 1437-1447
Acellular Corneal Transparency

ALBERT L. RUBIN
MARY JO POWERS
TERUO MIYATA
Research12 Mar 1971
Nature

Volume: 230, P: 120-121
Geomagnetic reversal paths

Carlo Laj
Alain Mazaud
Emilio Herrero-Bervera
Research10 Sept 1992
Nature

Volume: 359, P: 111-112
Human de novo mutation rates from a four-generation pedigree reference

Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set to understand the most fundamental processes underlying human genetic variation.

David Porubsky
Harriet Dashnow
Evan E. Eichler
ResearchOpen Access23 Apr 2025
Nature

Volume: 643, P: 427-436
Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences

Using voltage imaging, the authors show that interneurons in the hippocampus sharpen memory-encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron sensory representations during working memory in mice.

Jiannis Taxidis
Blake Madruga
Peyman Golshani
ResearchOpen Access22 Jul 2025
Nature Neuroscience

Volume: 28, P: 1946-1958
Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

Here, the authors provide molecular insight into the remarkable ability of Tardigrades to withstand high levels of radiation by demonstrating that their Dsup protein interacts with multiple surfaces of the nucleosome to protect the genome from oxidative DNA damage.

Rhiannon R. Aguilar
Laiba F. Khan
Jessica K. Tyler
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-17
Complex water networks visualized by cryogenic electron microscopy of RNA

Using cryogenic electron microscopy and a modelling approach, complex water networks in a ribozyme are visualized.

Rachael C. Kretsch
Shanshan Li
Wah Chiu
ResearchOpen Access11 Mar 2025
Nature

Volume: 642, P: 250-259

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