Nature Search

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Rik Ossenkoppele
Emma M. Coomans
Oskar Hansson
ResearchOpen Access16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1610-1621
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease

Synaptic loss contributes to cognitive decline in Alzheimer’s disease, but its spatial distribution remains poorly understood. Here, the authors show that synaptic loss is partially shaped by network connectivity and modulated by phosphorylated tau.

Ying Luan
Weiyi Wang
Fang Xie
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Biomarker-guided decision making in clinical drug development for neurodegenerative disorders

An increasing array of biomarkers available in blood, cerebrospinal fluid and through imaging are providing valuable proxies of disease processes in neurodegenerative disorders (NDDs). In their Review, Cummings and co-authors discuss the implementation of biomarkers in clinical trials across various NDDs, focusing on the context of use, to help expedite and de-risk drug development.

Jeffrey L. Cummings
Charlotte E. Teunissen
Philip Scheltens
Reviews04 Apr 2025
Nature Reviews Drug Discovery

Volume: 24, P: 589-609
Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Deep learning enhanced chemical imaging delineated polymorphic Aβ plaques in situ. Cored plaques were associated with increased Aβ1-40 and 3pE-42 deposition. A distinct, coarse-grained plaque phenotype was specific to AD, showed increased neuritic dystrophy and an Aβ-pattern similar to CAA.

Srinivas Koutarapu
Junyue Ge
Jörg Hanrieder
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Microglial activation and tau propagate jointly across Braak stages

Microglial activation and tau accumulation propagate together in patients with Alzheimer’s disease, suggesting an interaction that determines disease progression.

Tharick A. Pascoal
Andrea L. Benedet
Pedro Rosa-Neto
Research26 Aug 2021
Nature Medicine

Volume: 27, P: 1592-1599
Reply to “Acid inhibitors and allergy: comorbidity, causation and confusion”

Erika Jensen-Jarolim
Michael Kundi
Galateja Jordakieva
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-2
Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease

Trans-synaptic tau spread drives neurodegeneration in Alzheimer’s disease. This study shows that GAP-43, a marker of synaptic abnormality, is linked to faster tau spread, showing that synaptic changes may contribute to tau spreading in Alzheimer’s disease.

Nicolai Franzmeier
Amir Dehsarvi
Michael Schöll
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-10
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Abnormal levels of Aβ42 in the cerebrospinal fluid occur prior to a positive amyloid PET scan in the brain of individuals with Alzheimer’s disease and here the authors use this temporal pattern to identify individuals with very early stage AD. They show that Aβ fibrils start to accumulate in some of the regions of the default mode network and affect brain connectivity before neurodegeneration occurs.

Sebastian Palmqvist
Michael Schöll
Oskar Hansson
ResearchOpen Access31 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Ultrafast orbital tomography of a pentacene film using time-resolved momentum microscopy at a FEL

Ultrafast pulses are useful to investigate the electron dynamics in excited atoms, molecules and other complex systems. Here, the authors measure transient photoelectron momentum maps following the free-electron laser pulse-induced ionization of a bilayer pentacene thin film on Ag (110) by using time-resolved orbital tomography.

Kiana Baumgärtner
Marvin Reuner
Markus Scholz
ResearchOpen Access18 May 2022
Nature Communications

Volume: 13, P: 1-7
A multicentre validation study of the diagnostic value of plasma neurofilament light

Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.

Nicholas J. Ashton
Shorena Janelidze
Oskar Hansson
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Country-wide medical records infer increased allergy risk of gastric acid inhibition

Gastric acid inhibitors promote experimental allergy in animals, and have been linked to allergy risk in observational human studies. Here the authors show in a country-wide medical record analysis that allergy development risk is doubled in gastric acid inhibitor users, and is higher in women and in older age.

Galateja Jordakieva
Michael Kundi
Erika Jensen-Jarolim
ResearchOpen Access30 Jul 2019
Nature Communications

Volume: 10, P: 1-8
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
¹⁸F-AV-1451 in Parkinson’s Disease with and without dementia and in Dementia with Lewy Bodies

Ruben Smith
Michael Schöll
Oskar Hansson
ResearchOpen Access16 Mar 2018
Scientific Reports

Volume: 8, P: 1-6
Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

Michael Schöll
Stephen F. Carter
Agneta Nordberg
ResearchOpen Access10 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

Sarah E. Polk
Fredrik Öhman
David Berron
ResearchOpen Access10 May 2025
npj Digital Medicine

Volume: 8, P: 1-14
Publisher Correction: Microglial activation and tau propagate jointly across Braak stages

Tharick A. Pascoal
Andrea L. Benedet
Pedro Rosa-Neto
Amendments and Corrections15 Oct 2021
Nature Medicine

Volume: 27, P: 2048-2049
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Xue-Ru Fan
Ye He
Xi-Nian Zuo
ResearchOpen Access05 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Modeling brain network flexibility in networks of coupled oscillators: a feasibility study

Narges Chinichian
Michael Lindner
Rico Berner
ResearchOpen Access08 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

Most research into blood-based biomarkers for neurodegenerative disorders has so far focused on Alzheimer disease. In this Review, Aarsland and colleagues give an overview of the current status of blood-based biomarkers for the non-Alzheimer disease neurodegenerative disorders.

Nicholas J. Ashton
Abdul Hye
Dag Aarsland
Reviews22 Apr 2020
Nature Reviews Neurology

Volume: 16, P: 265-284
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

Meenu Rohini Rajan
Matus Sotak
Emma Börgeson
ResearchOpen Access28 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

Thomas K. Karikari
Andréa L. Benedet
Henrik Zetterberg
Research26 Oct 2020
Molecular Psychiatry

Volume: 26, P: 429-442
A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan
Yin-Shan Wang
Xi-Nian Zuo
ResearchOpen Access21 Aug 2023
Scientific Data

Volume: 10, P: 1-24

Search

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease

Biomarker-guided decision making in clinical drug development for neurodegenerative disorders

Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Microglial activation and tau propagate jointly across Braak stages

Reply to “Acid inhibitors and allergy: comorbidity, causation and confusion”

Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Ultrafast orbital tomography of a pentacene film using time-resolved momentum microscopy at a FEL

A multicentre validation study of the diagnostic value of plasma neurofilament light

Country-wide medical records infer increased allergy risk of gastric acid inhibition

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

¹⁸F-AV-1451 in Parkinson’s Disease with and without dementia and in Dementia with Lewy Bodies

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

Publisher Correction: Microglial activation and tau propagate jointly across Braak stages

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Modeling brain network flexibility in networks of coupled oscillators: a feasibility study

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

A longitudinal resource for population neuroscience of school-age children and adolescents in China

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