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Signal Transduction and Targeted Therapy (1)
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Advanced filters: Author: Michael Shing-Yan Huen Clear advanced filters

The PARP1–EXD2 axis orchestrates R-loop resolution to safeguard genome stability

Dysregulated R-loops can compromise genome stability, leading to pathological consequences. Li et al. demonstrate that R-loop-induced poly(ADP-ribose) polymerase 1 activation orchestrates exonuclease 3′–5′ domain-containing 2-mediated R-loop resolution, thereby safeguarding genomic integrity.

Zhaoshuang Li
Yu Liu
Jun Huang
Research27 Jun 2025
Nature Chemical Biology

Volume: 22, P: 205-216
TRAIP regulates replication fork recovery and progression via PCNA

Wanjuan Feng
Yingying Guo
Michael Shing-Yan Huen
ResearchOpen Access28 Jun 2016
Cell Discovery

Volume: 2, P: 1-14
Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes

Yi Ching Esther Wan
Tsz Chui Sophia Leung
Kui Ming Chan
ResearchOpen Access06 Mar 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-4