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Showing 1–4 of 4 results
Advanced filters: Author: Michael Smutny Clear advanced filters

  • The vertebrate brain forms during embryonic development through mechanical processes that are precisely coordinated in space and time. Here, the authors uncover how extrinsic forces regulate tissue flows and cellular rearrangements to shape the early neural plate during zebrafish gastrulation.

    • Angus Inman
    • Elisabeth Spiritosanto
    • Michael Smutny
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.

    • Michael Smutny
    • Zsuzsa Ákos
    • Carl-Philipp Heisenberg
    Research
    Nature Cell Biology
    Volume: 19, P: 306-317

  • Activation of the zygotic genome is a critical transition during development, though the link to tissue-specific gene regulation remains unclear. Here the authors demonstrate distinct functions for Satb2 before and after zygotic genome activation, highlighting the temporal coordination of these roles.

    • Saurabh J. Pradhan
    • Puli Chandramouli Reddy
    • Sanjeev Galande
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19