The lymphatic system transports interstitial fluid, immune cells and associated macromolecules to maintain body fluid homeostasis and regulate immune cell trafficking. This Review discusses the origins and organization of the lymphatic system and hybrid lymphatic-like vessels, their role in kidney function and disease, and the potential role of the lymphatic system as a therapeutic target.
- Michael D. Donnan
- Yael Kenig-Kozlovsky
- Susan E. Quaggin