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Showing 1–7 of 7 results
Advanced filters: Author: Michael Tymianski Clear advanced filters
  • Tat-NR2B9c, a PSD-95 inhibitor, is shown to reduce stroke-induced behavioural and neuroanatomical deficits in cynomolgous macaques when administered in the presence of an ischemic penumbra, suggesting the potential of PSD-95 inhibition as a neuroprotectant strategy for clinical investigation.

    • Douglas J. Cook
    • Lucy Teves
    • Michael Tymianski
    Research
    Nature
    Volume: 483, P: 213-217
  • Clinical trials in stroke intervention during the past year have yielded contrasting results. Endovascular therapies and procedures to reduce stroke risk caused by patent foramen ovale have failed to demonstrate superiority over standard medical treatments. By contrast, a trial of neuroprotection—traditionally thought to be ineffective in humans—offers hope.

    • Michael Tymianski
    News & Views
    Nature Reviews Neurology
    Volume: 10, P: 66-68
  • In a model of stroke, the authors show that suppressing the expression of TRPM7 in hippocampal CA1 neurons conferred resistance to ischemic death, preserving function and morphology. Also, TRPM7 suppression prevented ischemia-induced deficits in LTP and fear-associated and spatial navigational memory tasks.

    • Hong-Shuo Sun
    • Michael F Jackson
    • Michael Tymianski
    Research
    Nature Neuroscience
    Volume: 12, P: 1300-1307
  • Intracranial arterial aneurysms can pose life-threatening risks to patients, so understanding the cause and the progression of these lesions is important for choosing the right treatment. This Review argues that aneurysms are a symptom of an underlying vascular disease rather than constituting a disease on their own. The authors classify intracranial aneurysms by vessel wall pathology and demonstrate that knowledge of the morphology and pathology of this structure is important in determining the therapeutic approach.

    • Timo Krings
    • Daniel M. Mandell
    • Franz-Josef Hans
    Reviews
    Nature Reviews Neurology
    Volume: 7, P: 547-559
  • This perspective discusses newly discovered mechanisms leading to cellular ionic imbalances, as well as underappreciated signaling cascades that mediate cell death and that may add to the traditional glutamatergic mechanisms to which ischemic brain injury is ascribed. An integrated consideration of such new mechanisms may aid in formulating better therapies.

    • Michael Tymianski
    Reviews
    Nature Neuroscience
    Volume: 14, P: 1369-1373
  • A population of cervical interneurons is identified that can regulate diaphragm function by modulating phrenic motor neurons; targeting this small population of neurons may be a functional strategy to restore breathing after traumatic spinal cord injury.

    • Kajana Satkunendrarajah
    • Spyridon K. Karadimas
    • Michael G. Fehlings
    Research
    Nature
    Volume: 562, P: 419-422