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Showing 1–7 of 7 results
Advanced filters: Author: Michael V. Airola Clear advanced filters

  • Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for membrane binding and full functionality of lipins.

    • Weijing Gu
    • Shujuan Gao
    • Michael V. Airola
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.

    • Nivea Pereira de Sa
    • Adam Taouil
    • Michael V. Airola
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Lipin/Pah phosphatidic acid phosphatases generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Here authors determine structures of Tetrahymena thermophila Pah2 and identify an N-terminal amphipathic helix essential for membrane association.

    • Valerie I. Khayyo
    • Reece M. Hoffmann
    • Michael V. Airola
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Pascoa et al. reveal structures of the human ceramide synthase 6 and elucidate the enzyme’s mechanism. Furthermore, the work uncovers the basis of inhibition by the mycotoxin fumonisin B1.

    • Tomas C. Pascoa
    • Ashley C. W. Pike
    • David B. Sauer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 431-440