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Advanced filters: Author: Michaela Hinks Clear advanced filters

Single-molecule states link transcription factor binding to gene expression

A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor binding contribute to gene expression.

Benjamin R. Doughty
Michaela M. Hinks
William J. Greenleaf
Research20 Nov 2024
Nature

Volume: 636, P: 745-754
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

Screening recombinases identifies tools for inserting large sequences into the human genome.

Matthew G. Durrant
Alison Fanton
Patrick D. Hsu
ResearchOpen Access10 Oct 2022
Nature Biotechnology

Volume: 41, P: 488-499
Massively parallel RNA device engineering in mammalian cells with RNA-Seq

Synthetic RNA-based devices can dynamically control a wide range of processes. Here the authors develop a quantitative and high-throughput mammalian cell-based RNA-seq assay to efficiently engineer ribozyme switches.

Joy S. Xiang
Matias Kaplan
Christina D. Smolke
ResearchOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-16