Nature Search

Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant transformation of KRAS-mutant benign lesions.

Laura Antonucci
Na Li
Michael Karin
Research30 Jun 2025
Nature Cancer

Volume: 6, P: 1263-1282
Lens regeneration using endogenous stem cells with gain of visual function

A new procedure for cataract removal that preserves lens epithelial progenitor cells in mammals, which require Pax6 and Bmi1 for their self-renewal, achieves lens regeneration in rabbits, macaques and in infants with cataracts.

Haotian Lin
Hong Ouyang
Yizhi Liu
Research09 Mar 2016
Nature

Volume: 531, P: 323-328
Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function

Haotian Lin
Hong Ouyang
Yizhi Liu
Amendments and Corrections30 Nov 2016
Nature

Volume: 541, P: 558
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

Circulating tumour DNA is used as a biomarker for cancer diagnosis. Here, the authors identified a DNA methylation biomarker for hepatocellular carcinoma and developed diagnostic and prognostic models to predict specificity and survival of patients.

Rui-hua Xu
Wei Wei
Kang Zhang
Research09 Oct 2017
Nature Materials

Volume: 16, P: 1155-1161
Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization

The genome is folded in 3-dimensions, though the lack of robust ultra-resolution imaging makes this difficult to visualise. Here, the authors present 3D-EMISH that combines serial block-face scanning electron microscopy with in situ hybridization.

Paweł Trzaskoma
Błażej Ruszczycki
Grzegorz M. Wilczyński
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-9
Chromatin remodeling and extragenic transcription at the MHC class II locus control region

Krzysztof Masternak
Nicolas Peyraud
Walter Reith
Research13 Jan 2003
Nature Immunology

Volume: 4, P: 132-137
Continuously high Wolbachia incidence in flea populations may result from dual-strain infections with divergent effects

Ron Flatau
Aleksandra I. Krawczyk
Hadas Hawlena
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Required enhancer–matrin-3 network interactions for a homeodomain transcription program

The POU homeodomain transcription factor Pit1 is required for pituitary development; here Pit1-occupied enhancers are shown to interact with the nuclear architecture components matrin-3 and Satb1, and this association is required for activation of Pit1-regulated enhancers and coding target genes.

Dorota Skowronska-Krawczyk
Qi Ma
Michael G. Rosenfeld
Research03 Aug 2014
Nature

Volume: 514, P: 257-261
Ischemia-reperfusion injury and the risk of hepatocellular carcinoma recurrence after deceased donor liver transplantation

Michał Grąt
Marek Krawczyk
Krzysztof Zieniewicz
ResearchOpen Access12 Jun 2018
Scientific Reports

Volume: 8, P: 1-13
Limitations of predicting microvascular invasion in patients with hepatocellular cancer prior to liver transplantation

Michał Grąt
Jan Stypułkowski
Marek Krawczyk
ResearchOpen Access06 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases

Jerzy Ostrowski
Krzysztof Goryca
Teresa Starzynska
ResearchOpen Access10 May 2019
Scientific Reports

Volume: 9, P: 1-11
Stabilization and racetrack application of asymmetric Néel skyrmions in hybrid nanostructures

Mateusz Zelent
Mathieu Moalic
Maciej Krawczyk
ResearchOpen Access21 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Bimeron clusters in chiral antiferromagnets

Xiaoguang Li
Laichuan Shen
Yan Zhou
ResearchOpen Access09 Nov 2020
npj Computational Materials

Volume: 6, P: 1-9

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Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

Lens regeneration using endogenous stem cells with gain of visual function

Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization

Chromatin remodeling and extragenic transcription at the MHC class II locus control region

Continuously high Wolbachia incidence in flea populations may result from dual-strain infections with divergent effects

Required enhancer–matrin-3 network interactions for a homeodomain transcription program

Ischemia-reperfusion injury and the risk of hepatocellular carcinoma recurrence after deceased donor liver transplantation

Limitations of predicting microvascular invasion in patients with hepatocellular cancer prior to liver transplantation

Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases

Stabilization and racetrack application of asymmetric Néel skyrmions in hybrid nanostructures

Bimeron clusters in chiral antiferromagnets

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