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Showing 1–6 of 6 results
Advanced filters: Author: Michal Levo Clear advanced filters

  • Gene activity levels predict how often and how strongly genes turn on and off. Using live imaging in fruit fly embryos, the authors uncover a conserved rule linking transcriptional bursts to gene activity across time, space and species.

    • Po-Ta Chen
    • Michal Levo
    • Thomas Gregor
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1959-1971

  • In Drosophila, there are extensive physical and functional associations of distant paralogous genes, including co-regulation by shared enhancers and co-transcriptional initiation over distances of nearly 250 kilobases.

    • Michal Levo
    • João Raimundo
    • Michael S. Levine
    Research
    Nature
    Volume: 605, P: 754-760

  • Eran Segal and colleagues measure the promoter activities of 70 different constructed promoter variants and find that poly(dA:dT) tracts significantly affect transcriptional outcome. They suggest that this is mediated by altering nucleosome organization and that these sequences can be manipulated to fine tune regulation of gene expression.

    • Tali Raveh-Sadka
    • Michal Levo
    • Eran Segal
    Research
    Nature Genetics
    Volume: 44, P: 743-750

  • The authors use genome editing and live imaging to visualize physical enhancer–promoter interaction and transcription at the single-cell level in Drosophila embryos. They show that sustained proximity of an enhancer to its target is required for transcription.

    • Hongtao Chen
    • Michal Levo
    • Thomas Gregor
    Research
    Nature Genetics
    Volume: 50, P: 1296-1303

  • Analyzing the effects of multiple promoter motifs on gene expression can be a laborious process. Sharon et al. present a high-throughput method to measure the expression of thousands of designed yeast promoters in a single experiment and use it to reveal new features of transcriptional regulation.

    • Eilon Sharon
    • Yael Kalma
    • Eran Segal
    Research
    Nature Biotechnology
    Volume: 30, P: 521-530

  • Gene-regulatory DNA elements control complex spatiotemporal patterns of gene expression, and alterations to these sequences are commonly associated with inter-individual phenotypic variation and human disease. This Review discusses our latest understanding of how different layers of information in these sequences control the binding of regulators and influence gene expression outcomes.

    • Michal Levo
    • Eran Segal
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 453-468