Nature Search

Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Here, Israeli and Finkel et al. perform genome-wide CRISPR knockout screens to identify host factors required for the infection with SARS-CoV-2 and two additionally variants of concern, Alpha and Beta, unveiling shared and differential host pathways required by the variants, and demonstrate GATA6 is critical for SARS-CoV-2 viral entry through modulation of ACE2 expression.

Ma’ayan Israeli
Yaara Finkel
Adi Bercovich-Kinori
ResearchOpen Access25 Apr 2022
Nature Communications

Volume: 13, P: 1-16
The activating receptor NKp46 is essential for the development of type 1 diabetes

Natural killer cells infiltrate the pancreas during type 1 diabetes. Mandelboim and co-workers find that the natural killer receptor NKp46 recognizes ligands on pancreatic beta cells and is essential for full diabetes development.

Chamutal Gur
Angel Porgador
Ofer Mandelboim
Research20 Dec 2009
Nature Immunology

Volume: 11, P: 121-128
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D

The mechanisms controlling expression of the stress-induced NKG2D ligands MICA and MICB are not fully understood. Mandelboim and colleagues suggest that microRNAs maintain low MICA and MICB expression in the absence of cell stress.

Noam Stern-Ginossar
Chamutal Gur
Ofer Mandelboim
Research01 Aug 2008
Nature Immunology

Volume: 9, P: 1065-1073
Author Correction: Immunogenicity and efficacy of fourth BNT162b2 and mRNA1273 COVID-19 vaccine doses; three months follow-up

Michal Canetti
Noam Barda
Gili Regev-Yochay
Amendments and CorrectionsOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1
Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons

Roni Winkler
Ella Gillis
Noam Stern-Ginossar
Amendments and Corrections11 Jan 2019
Nature Immunology

Volume: 20, P: 243
Immunogenicity and efficacy of fourth BNT162b2 and mRNA1273 COVID-19 vaccine doses; three months follow-up

Here the authors provide immunogenicity and efficacy data at 3-month follow-up for vaccinees who have received a fourth dose of either mRNA1273 or BNT162b2. Both vaccines were highly effective against substantial symptomatic disease, but had little effect against SARS-CoV-2 infection.

Michal Canetti
Noam Barda
Gili Regev-Yochay
ResearchOpen Access13 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Characterising the asynchronous resurgence of common respiratory viruses following the COVID-19 pandemic

COVID-19-related non-pharmaceutical interventions impacted the circulation of other pathogens. Here, the authors compile a global viral activity dataset and compare the timing of resurgence of seven common respiratory viruses following the relaxation of interventions across different geographical regions.

Chenkai Zhao
Tiantian Zhang
Marie N. Billard
ResearchOpen Access13 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Disinfection of SARS-CoV-2 by UV-LED 267 nm: comparing different variants

Nofar Atari
Hadas Mamane
Yoram Gerchman
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-6
A method to identify respiratory virus infections in clinical samples using next-generation sequencing

Talia Kustin
Guy Ling
Michal Mandelboim
ResearchOpen Access22 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Cell composition analysis of bulk genomics using single-cell data

Cell Population Mapping (CPM) leverages single-cell RNA-seq data as a rich reference to predict the composition of cell types and cell states from bulk RNA-seq data.

Amit Frishberg
Naama Peshes-Yaloz
Irit Gat-Viks
Research18 Mar 2019
Nature Methods

Volume: 16, P: 327-332
m⁶A modification controls the innate immune response to infection by targeting type I interferons

RNAs can be dynamically modified by N⁶-methylation of adenosine (m⁶A), which leads to their destabilization. Stern-Ginossar and colleagues demonstrate a role for m⁶A modification of host transcripts encoding type I interferons during viral infection.

Roni Winkler
Ella Gillis
Noam Stern-Ginossar
Research17 Dec 2018
Nature Immunology

Volume: 20, P: 173-182
Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression

Ariella Glasner
Batya Isaacson
Ofer Mandelboim
ResearchOpen Access12 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5–induced eosinophil development

Paired immunoglobulin-like receptors (PIRs) recognize β2-microglobulin. Munitz and colleagues show that PIR-A and PIR-B have opposing roles in eosinophil development in response to interleukin 5 in the bone marrow.

Netali Ben Baruch-Morgenstern
Dana Shik
Ariel Munitz
Research10 Nov 2013
Nature Immunology

Volume: 15, P: 36-44

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