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Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

In a single-arm, non-randomized trial, neoadjuvant atezolizumab therapy in a large cohort of patients with resectable non-small cell lung cancer was safe and the study met its primary end point of major pathological response ≥15%.

Jamie E. Chaft
Filiz Oezkan
Justin D. Blasberg
ResearchOpen Access12 Sept 2022
Nature Medicine

Volume: 28, P: 2155-2161
Author Correction: Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

Jamie E. Chaft
Filiz Oezkan
Justin D. Blasberg
Amendments and CorrectionsOpen Access10 Oct 2023
Nature Medicine

Volume: 30, P: 303
The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors

Whether differentiation of regulatory and conventional T cells in the thymus requires similar T-cell receptor affinity is not known. Here, the authors show that cells expressing the same T-cell receptor selected on the same ligand can give rise to both lineages, but different sensitivity to negative selection separates their T-cell receptor repertoires.

Lukasz Wojciech
Alicja Ignatowicz
Leszek Ignatowicz
Research01 Oct 2014
Nature Communications

Volume: 5, P: 1-10
Genome sequence analysis provides evidence that a boreal crustacean colonised Svalbard well before the ongoing Atlantification of the Arctic

Hedvig Kriszta Csapó
Jan Marcin Weslawski
Nicolas Bierne
ResearchOpen Access23 Aug 2025
Heredity

Volume: 134, P: 558-566
Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Mycobacterium tuberculosis (M.tb) infection of human alveolar macrophages reveals a variably expressed gene network with inter-individual variability, guiding future studies to determine individual risk of M.tb infection and tuberculosis disease.

Wolfgang Sadee
Ian H. Cheeseman
Larry S. Schlesinger
ResearchOpen Access23 Jun 2025
Communications Biology

Volume: 8, P: 1-13
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (T_reg) cells constitute most T_reg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic T_reg cells and not induced T_reg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.

Anna Cebula
Michal Seweryn
Leszek Ignatowicz
Research28 Apr 2013
Nature

Volume: 497, P: 258-262
Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis

Druszczynska Magdalena
Seweryn Michal
Szewczyk Rafał
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-13

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Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

Author Correction: Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors

Genome sequence analysis provides evidence that a boreal crustacean colonised Svalbard well before the ongoing Atlantification of the Arctic

Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis

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Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

Author Correction: Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

The same self-peptide selects conventional and regulatory CD4+ T cells with identical antigen receptors

Genome sequence analysis provides evidence that a boreal crustacean colonised Svalbard well before the ongoing Atlantification of the Arctic

Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis

Search

Quick links

The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors