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Showing 1–7 of 7 results
Advanced filters: Author: Michalis Agathocleous Clear advanced filters

  • It is unclear whether proliferating and differentiating cells produce energy through different metabolic pathways. Harris and colleagues show, in the embryonic Xenopus retina, that dividing progenitors use glycogen for glycolysis, and that a transition to oxidative phosphorylation occurs as cells differentiate.

    • Michalis Agathocleous
    • Nicola K. Love
    • William A. Harris
    Research
    Nature Cell Biology
    Volume: 14, P: 859-864

  • Resistance to menin inhibitors often occurs in the initially sensitive MLL-rearranged (MLLr) leukemias. Here authors discover that inhibition of guanine nucleotide biosynthesis leads to myeloid differentiation and sensitization to menin inhibitors in leukemia stem cells of MLLr leukemia.

    • Xiangguo Shi
    • Minhua Li
    • Daisuke Nakada
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Severe COVID-19 is characterized by an accumulation of and functional changes in neutrophils. Using metabolomics, the authors demonstrate that neutrophils display a reduction in GAPDH activity in severe COVID-19 and that GAPDH inhibition promotes neutrophil extracellular trap formation.

    • Yafeng Li
    • Jessica S. Hook
    • Michalis Agathocleous
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Human melanoma cells grown in mice experience high levels of oxidative stress in the bloodstream such that few metastasizing cells survive to form tumours; the rare melanoma cells that successfully metastasize undergo metabolic changes that increase their capacity to withstand this stress, and antioxidant treatments increase metastasis formation by human melanoma cells, while inhibiting antioxidant pathways had the reverse effect.

    • Elena Piskounova
    • Michalis Agathocleous
    • Sean J. Morrison
    Research
    Nature
    Volume: 527, P: 186-191

  • The effect of vitamin C deprivation on mouse germline development is analysed, revealing that maternal vitamin C is required for proper DNA demethylation and the development of fetal oocytes, whereas the lack of vitamin C during pregnancy leads to reduced female fecundity in the offspring.

    • Stephanie P. DiTroia
    • Michelle Percharde
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 573, P: 271-275