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Showing 1–12 of 12 results
Advanced filters: Author: Michel Burnier Clear advanced filters

  • Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells.

    • Georg B Ehret
    • Teresa Ferreira
    • Patricia B Munroe
    Research
    Nature Genetics
    Volume: 48, P: 1171-1184

  • A reduction of salt intake to <5 g sodium chloride per day is generally advised for patients with chronic kidney disease. However, hard evidence to support this recommendation is lacking. New data from Fan et al. suggest that very strict sodium limits might be harmful in patients with renal disease.

    • Michel Burnier
    • Gregoire Wuerzner
    News & Views
    Nature Reviews Nephrology
    Volume: 10, P: 363-364

  • Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated with serum urate concentrations and confirm 10 known loci, characterize their associations with gout and include a network analysis suggesting a role for inhibins-activins pathways in regulating urate homeostasis.

    • Anna Köttgen
    • Eva Albrecht
    • Christian Gieger
    Research
    Nature Genetics
    Volume: 45, P: 145-154

  • Cristen Willer and colleagues report genome-wide association analyses for blood lipid levels in 188,578 individuals. They identify 62 loci newly associated with blood lipid levels, refine the association signals at 12 loci and examine associations with cardiovascular and metabolic traits.

    • Cristen J Willer
    • Ellen M Schmidt
    • Gonçalo R Abecasis
    Research
    Nature Genetics
    Volume: 45, P: 1274-1283

  • Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

    • Dmitry Shungin
    • Thomas W. Winkler
    • Karen L Mohlke
    Research
    Nature
    Volume: 518, P: 187-196

  • Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.

    • Antonia E. Schantl
    • Anja Verhulst
    • Jean-Christophe Leroux
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Here, the authors review techniques for cardiovascular diagnosis, screening and monitoring in patients with CKD, including approaches to the diagnosis of cardiac ischaemia, left ventricular hypertrophy and dysfunction, arrhythmia, cerebrovascular disease, peripheral arterial disease, arterial stiffness and hypertension.

    • Carmine Zoccali
    • Patrick B. Mark
    • Andrzej Wiecek
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 733-746

  • Variation in the promoter of the gene encoding uromodulin, the most abundant protein in urine, affects the individual risk of developing hypertension or chronic kidney disease. Luca Rampoldi, Olivier Devuyst and their colleagues show that the uromodulin risk alleles are associated with higher levels of uromodulin expression. This can promote hypertension, by stimulating sodium reabsorption by the loop of Henle in the kidney, and kidney damage in both mice and humans.

    • Matteo Trudu
    • Sylvie Janas
    • Luca Rampoldi
    Research
    Nature Medicine
    Volume: 19, P: 1655-1660