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Showing 1–10 of 10 results
Advanced filters: Author: Michel Chonchol Clear advanced filters

  • Elevated levels of fibrobast growth factor 23 (FGF-23) are associated with cardiovascular and all-cause mortality in patients with kidney disease. A secondary analysis of the EVOLVE trial reports that cinacalcet-induced reductions in FGF-23 were associated with a reduced risk of cardiovascular events in patients with secondary hyperparathyroidism on dialysis.

    • Anna Jovanovich
    • Michel Chonchol
    News & Views
    Nature Reviews Nephrology
    Volume: 11, P: 572-573

  • Cystatin C was introduced as a potential alternative or supplement to the estimation of glomerular filtration rate (GFR) using creatinine. Although cystatin C is well supported as a better predictor of outcomes than creatinine, its reflection of actual renal function compared with creatinine is widely debated. A new study by Rule et al. asserts that cystatin-C-based estimated GFR is biased by non-GFR-associated risk factors for chronic kidney disease.

    • Kristen L. Jablonski
    • Michel Chonchol
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 318-319

  • The severity and extent of cardiovascular complications in patients with chronic kidney disease is disproportionate to the number and severity of traditional risk factors, such as diabetes and hypertension. Could uremia-related factors—including anemia, microalbuminuria, inflammation, oxidative stress, and abnormalities in bone and mineral metabolism—account for this discrepancy? Authors from the University of Colorado Health Sciences Center weigh up the evidence from randomized controlled trials of interventions for these so-called 'nontraditional' risk factors.

    • Jessica Kendrick
    • Michel B Chonchol
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 672-681

  • During 2013, a meta-analysis provided evidence that cystatin C improves estimated glomerular filtration rate in cardiovascular risk categorization in chronic kidney disease (CKD). Another study showed that low diastolic blood pressure (DBP) is harmful in patients with CKD, challenging the paradigm of treating elevated systolic blood pressure regardless of DBP. Overall, mortality rates in CKD have decreased but further improvement is required.

    • Jessica Kendrick
    • Michel Chonchol
    News & Views
    Nature Reviews Nephrology
    Volume: 10, P: 71-72

  • Declining NAD+ levels have been linked to aging-associated pathologies. Here the authors present results of a double-blind, randomized crossover trial on 30 healthy middle-aged individuals to show that nicotinamide riboside effectively elevates NAD+ levels in humans, appears to be well tolerated, and may have potential to improve cardiovascular parameters.

    • Christopher R. Martens
    • Blair A. Denman
    • Douglas R. Seals
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The use of statins as a line of primary prevention in individuals at low risk of cardiovascular events is an area of debate. The most recent meta-analysis from the Cholesterol Treatment Trialists' (CTT) Collaboration suggests that present guidelines for prescribing statin therapy may need to be reconsidered.

    • Kristen L. Jablonski
    • Michel Chonchol
    News & Views
    Nature Reviews Nephrology
    Volume: 8, P: 440-441

  • Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.

    • Mihai G Netea
    • Frances Balkwill
    • Charles A Dinarello
    Comments & Opinion
    Nature Immunology
    Volume: 18, P: 826-831