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Showing 1–2 of 2 results
Advanced filters: Author: Michel Choudalakis Clear advanced filters

  • Mammalian oocytes and embryos undergo major epigenetic changes. Here, genome-wide mapping of the histone variant H2A.Z across mouse oogenesis and early embryogenesis reveals distinct maternal, embryonic and persistent enrichment patterns, linking histone variant dynamics to epigenetic inheritance, repeats and developmental reprogramming.

    • Madeleine Fosslie
    • Erkut Ilaslan
    • Mads Lerdrup
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • The SET-domain containing protein 2 (SETD2) is a protein lysine methyltransferase that has been shown to methylate the super-substrate peptide ssK36 100 times faster than the corresponding natural H3K36 peptide. Here, a combination of molecular dynamics simulations and biochemical experiments are applied to identify the mechanisms responsible for the increased activity of SETD2 towards ssK36.

    • Philipp Schnee
    • Michel Choudalakis
    • Albert Jeltsch
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-16