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Showing 1–3 of 3 results
Advanced filters: Author: Michel Kather Clear advanced filters

  • Combined hepatocellular-cholangiocarcinomas (cHCC-CCA) are challenging to diagnose, as they exhibit features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA). Here, the authors use deep learning to re-classify cHCC-CCA tumours into HCC or ICCA based on histopathology images.

    • Julien Calderaro
    • Narmin Ghaffari Laleh
    • Jakob Nikolas Kather
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal moiety of rubromycin polyketides, driven by flavin-dependent enzymes, and characterize reaction intermediates.

    • Britta Frensch
    • Thorsten Lechtenberg
    • Robin Teufel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12