Nature Search

Lipid-soluble toxins thought to be specific for Na⁺ channels block Ca²⁺ channels in neuronal cells

Georges Romey
Michel Lazdunski
Research06 May 1982
Nature

Volume: 297, P: 79-80
K_vLQT1 and IsK (minK) proteins associate to form the I_KS cardiac potassium current

Jacques Barhanin
Florian Lesage
Georges Romey
Research07 Nov 1996
Nature

Volume: 384, P: 78-80
Expression of apamin receptor in muscles of patients with myotonic muscular dystrophy

Jean-François Renaud
Claude Desnuelle
Michel Lazdunski
Research20 Feb 1986
Nature

Volume: 319, P: 678-680
Restoration of dysgenic muscle contraction and calcium channel function by co-culture with normal spinal cord neurons

François Rieger
Roland Bournaud
Michel Lazdunski
Research10 Dec 1987
Nature

Volume: 330, P: 563-566
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

Eric Lingueglia
Guy Champigny
Pascal Barbry
Research14 Dec 1995
Nature

Volume: 378, P: 730-733
A proton-gated cation channel involved in acid-sensing

Rainer Waldmann
Guy Champigny
Michel Lazdunski
Research13 Mar 1997
Nature

Volume: 386, P: 173-177
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

Wilfried Dalemans
Pascal Barbry
Michel Lazdunski
Research26 Dec 1991
Nature

Volume: 354, P: 526-528
The protein IsK is a dual activator of K⁺ and CI⁻ channels

Bernard Attali
Eric Guillemare
Jacques Barhanin
Research28 Oct 1993
Nature

Volume: 365, P: 850-852
Selective blockade of Ca_v1.2 (α1C) versus Ca_v1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

L-type voltage-gated calcium channels are involved in multiple physiological functions. Here the authors identify calciseptine, a toxin purified from black mamba venom, as a selective inhibitor of Ca_v1.2 L-type Ca²⁺ channels.

Pietro Mesirca
Jean Chemin
Joël Nargeot
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Inhalational anesthetics activate two-pore-domain background K⁺ channels

Amanda J. Patel
Eric Honoré
Michel Lazdunski
Research01 May 1999
Nature Neuroscience

Volume: 2, P: 422-426
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

Michel Mazzuca
Catherine Heurteaux
Michel Lazdunski
Research15 Jul 2007
Nature Neuroscience

Volume: 10, P: 943-945
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

A slight mechanical pressure applied to healthy skin results in blood vessel dilation, preserving blood flow. Defects in this vasodilatory response lead to an increased risk of pressure ulcers. Fromy et al. identify the neuronal mechanosensor that mediates this response in both rodents and humans: the ion channel Asic3.

Bérengère Fromy
Eric Lingueglia
Michel Lazdunski
Research29 Jul 2012
Nature Medicine

Volume: 18, P: 1205-1207
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

Wanping Jiang
William J. Swiggard
Michel C. Nussenzweig
Research11 May 1995
Nature

Volume: 375, P: 151-155
Activation of TREK-1 by morphine results in analgesia without adverse side effects

Opioid analgesic drugs act at opioid receptors to exert analgesic effects, but they also exert adverse side effects. In this study, the authors show that the TREK-1 potassium channel is responsible for mediating the analgesic effects of morphine but not the adverse side effects.

Maïly Devilliers
Jérôme Busserolles
Alain Eschalier
Research17 Dec 2013
Nature Communications

Volume: 4, P: 1-9
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

Catherine Heurteaux
Guillaume Lucas
Michel Lazdunski
Research13 Aug 2006
Nature Neuroscience

Volume: 9, P: 1134-1141
Black mamba venom peptides target acid-sensing ion channels to abolish pain

A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.

Sylvie Diochot
Anne Baron
Eric Lingueglia
Research03 Oct 2012
Nature

Volume: 490, P: 552-555
Bi-directional effects of GABA_B receptor agonists on the mesolimbic dopamine system

Hans G Cruz
Tatiana Ivanova
Christian Lüscher
Research25 Jan 2004
Nature Neuroscience

Volume: 7, P: 153-159
Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice

Anne Vincent
Aurélie Covinhes
Stéphanie Barrère-Lemaire
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
Pseudomonas Aeruginosa Virulence Factors Delay Airway Epithelial Wound Repair by Altering the Actin Cytoskeleton and Inducing Overactivation of Epithelial Matrix Metalloproteinase–2

Sophie de Bentzmann
Myriam Polette
Edith Puchelle
Research01 Feb 2000
Laboratory Investigation

Volume: 80, P: 209-219
The neuronal background K_2P channels: focus on TREK1

TREK1 is the most extensively studied of the mammalian two-pore-forming K⁺channels and is widely expressed in the brain. Honoré reviews the functional properties of TREK1 and describes recent results indicating its important roles in CNS function and disease.

Eric Honoré
Reviews01 Apr 2007
Nature Reviews Neuroscience

Volume: 8, P: 251-261

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