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Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before symptom onset.

Rachael I. Scahill
Mena Farag
Sarah J. Tabrizi
ResearchOpen Access17 Jan 2025
Nature Medicine

Volume: 31, P: 807-818
Age-related vulnerability of the human brain connectome

Massimo Filippi
Camilla Cividini
Federica Agosta
ResearchOpen Access06 Jul 2023
Molecular Psychiatry

Volume: 28, P: 5350-5358

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Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

Age-related vulnerability of the human brain connectome

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