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Showing 1–5 of 5 results
Advanced filters: Author: Michelle Cung Clear advanced filters

  • The mediators of bone-fat axis remain largely unknown. Here, the authors show SHN3 gene-deficiency in bone can protect mouse models from weight gain driven by diet-induced obesity through secreting a bone-derived cytokine, C-fragment of SLIT2, which could stimulate adipocyte browning.

    • Zan Li
    • Baohong Shi
    • Ren Xu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.

    • Jun Sun
    • Dong Yeon Shin
    • Matthew B. Greenblatt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Vertebral osteoblasts in mouse and human are formed from a precursor skeletal stem cell population that is distinct from long bone skeletal stem cells in function, location and transcriptional programme.

    • Jun Sun
    • Lingling Hu
    • Matthew B. Greenblatt
    Research
    Nature
    Volume: 621, P: 602-609

  • The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.

    • Seoyeon Bok
    • Alisha R. Yallowitz
    • Matthew B. Greenblatt
    Research
    Nature
    Volume: 621, P: 804-812

  • Neurofibromatosis type I (NF1) is characterized by prominent skeletal abnormalities mediated in part by aberrant ERK pathway activation due to NF1 loss-of-function. Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation and that MEKK2 inhibitors, including ponatinib, ameliorate skeletal defects in a mouse model of NF1.

    • Seoyeon Bok
    • Dong Yeon Shin
    • Matthew B. Greenblatt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10