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Showing 1–8 of 8 results
Advanced filters: Author: Michelle L. Robinette Clear advanced filters

  • ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.

    • Michelle L. Robinette
    • Jennifer K. Bando
    • Marco Colonna
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Colonna and colleagues generate mice in which both type 1 innate lymphoid cells and natural killer cells selectively lack SMAD4, which promotes canonical signaling of all cytokines of the TGF-β family. Unexpectedly, SMAD4 deficiency does not visibly affect the differentiation of type 1 innate lymphoid cells but instead alters the phenotype of conventional natural killer cells.

    • Victor S Cortez
    • Tyler K Ulland
    • Marco Colonna
    Research
    Nature Immunology
    Volume: 18, P: 995-1003

  • Clonal haematopoiesis — the occurrence of somatic mutations and mosaic chromosomal alterations in blood cells — is associated with age-related diseases, autoimmunity, immunodeficiency and haematological neoplasms. This Review describes how myeloid and lymphoid cell dysregulation underlies this association.

    • Roger Belizaire
    • Waihay J. Wong
    • Benjamin L. Ebert
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 595-610

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703