Nature Search

Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia

Michelle M. Le Beau
Manuel O. Diaz
Janet D. Rowley
Research21 Feb 1985
Nature

Volume: 313, P: 709-711
The human met oncogene is related to the tyrosine kinase oncogenes

Michael Dean
Morag Park
George F. Vande Woude
Research28 Nov 1985
Nature

Volume: 318, P: 385-388
One FISH, two FISH, red FISH, blue FISH

Michelle M. Le Beau
News & Views01 Apr 1996
Nature Genetics

Volume: 12, P: 341-344
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Kazuya Yamagata
Naohisa Oda
Graeme I. Bell
Research05 Dec 1996
Nature

Volume: 384, P: 455-458
Evidence for two distinct c-src loci on human chromosomes 1 and 20

Michelle M. Le Beau
Carol A. Westbrook
Janet D. Rowley
Research01 Nov 1984
Nature

Volume: 312, P: 70-71
Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia

Michelle M. Le Beau
Carol A. Westbrook
Moshe Oren
Research29 Aug 1985
Nature

Volume: 316, P: 826-828
TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

The shortening of telomeres—a structure that protects chromosome ends—is associated with cellular aging. Here, Wood et al.present evidence that interaction between the telomere-binding protein TRF2 and lamin A/C facilitates the formation of interstitial t-loops and stabilizes telomeres.

Ashley M. Wood
Jannie M. Rendtlew Danielsen
Steven T. Kosak
ResearchOpen Access17 Nov 2014
Nature Communications

Volume: 5, P: 1-9
MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

Brooke M Emerling
Jeannette Bonifas
Kevin M Shannon
Research09 Jul 2002
Oncogene

Volume: 21, P: 4849-4854
Correction: Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

Zejuan Li
Hao Huang
Jianjun Chen
Amendments and Corrections10 Apr 2018
Nature Communications

Volume: 9, P: 1
Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Jason X. Cheng
Li Chen
James W. Vardiman
Amendments and CorrectionsOpen Access06 Jun 2018
Nature Communications

Volume: 9, P: 1
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

This paper reports the identification of high-frequency deletions in the Ikaros gene in acute lymphoblastic leukaemia cases that are characterized by BCR-ABL1 translocations. In contrast, BCR-ABL1 CML is not associated with Ikaros deletions in chronic phase patients, but are often acquired during progression to blast crisis. These deletions lead to expression of altered transcripts. In contrast to previous models suggesting that these transcripts result from aberrant alternative splicing, it is shown that the deletions found are due to aberrant RAG-mediated recombination.

Charles G. Mullighan
Christopher B. Miller
James R. Downing
Research13 Apr 2008
Nature

Volume: 453, P: 110-114
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Joshua Wechsler
Marianne Greene
John D. Crispino
Research12 Aug 2002
Nature Genetics

Volume: 32, P: 148-152
Hay in a haystack

Although some diseases occur when both copies of a gene are mutated, mutation of just one copy of certain tumour-suppressor genes promotes tumorigenesis. Identifying such mutations is arduous, but worth the effort.

Kevin M. Shannon
Michelle M. Le Beau
News & Views16 Jan 2008
Nature

Volume: 451, P: 252-253
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.

Wei-Yu Lin
Sarah E. Fordham
James M. Allan
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Therapy-related myeloid neoplasms: when genetics and environment collide

Therapy-related myeloid neoplasms occur as a late complication following chemotherapy and/or radiotherapy administered for a primary condition. In this Review, McNerneyet al. discuss recent studies that have improved our understanding of the aetiology of this disease.

Megan E. McNerney
Lucy A. Godley
Michelle M. Le Beau
Reviews24 Aug 2017
Nature Reviews Cancer

Volume: 17, P: 513-527
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

HOX9AandMEIS1are key oncogenes in MLL-rearranged leukaemia. miRNA-196b is shown here to directly suppress their expression and delay MLL-fusion-mediated leukaemia, but to also cause an aggressive leukaemia phenotype when expressed ectopically, suggesting that it targets tumour suppressors as well.

Zejuan Li
Hao Huang
Jianjun Chen
Research21 Feb 2012
Nature Communications

Volume: 3, P: 1-12
RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m⁵C) and RNA:m⁵C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response and resistance.

Jason X. Cheng
Li Chen
James W. Vardiman
ResearchOpen Access21 Mar 2018
Nature Communications

Volume: 9, P: 1-16
Dissecting the role of aberrant DNA methylation in human leukaemia

Chronic myeloid leukaemia is characterized by the genetic translocation t(9;22) encoding for BCR-ABL oncogene; however, the molecular mechanisms of disease progression are poorly understood. Here Amabile et al. show that aberrant methylation is promoted by BCR-ABL, driving the evolution of the disease.

Giovanni Amabile
Annalisa Di Ruscio
Daniel G. Tenen
Research22 May 2015
Nature Communications

Volume: 6, P: 1-10
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.

Xi Jiang
Chao Hu
Jianjun Chen
ResearchOpen Access26 Apr 2016
Nature Communications

Volume: 7, P: 1-15
Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Wei-Yu Lin
Sarah E. Fordham
James M. Allan
Amendments and CorrectionsOpen Access04 Jan 2022
Nature Communications

Volume: 13, P: 1
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

Tokhir Dadaev
Edward J. Saunders
Zsofia Kote-Jarai
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-19
Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements

Arnaud Coquelle
Lorène Rozier
Michelle Debatisse
Research25 Oct 2002
Oncogene

Volume: 21, P: 7671-7679
Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Haematopoietic stem cell (HSC) function is known to degrade with age; here, replication stress is shown to be a potent driver of the functional decline of HSCs during physiological ageing in mice due to decreased expression of mini-chromosome maintenance helicase components and reduced activity of the DNA replication machinery.

Johanna Flach
Sietske T. Bakker
Emmanuelle Passegué
Research30 Jul 2014
Nature

Volume: 512, P: 198-202
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

Frank Rosenbauer
Katharina Wagner
Daniel G Tenen
Research16 May 2004
Nature Genetics

Volume: 36, P: 624-630
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis

Scott Lowe and colleagues investigate regulation of Ras signaling during leukemogenesis and show that negative regulators Spry4 and Nf1 prevent transformation to aggressive acute myeloid leukemia in mice.

Zhen Zhao
Chi-Chao Chen
Scott W Lowe
Research30 Mar 2015
Nature Genetics

Volume: 47, P: 539-543
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Asha Singanamalli
Haibo Wang
Kristin Fargher
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
Amendments and CorrectionsOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-5
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18

Search

Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia

The human met oncogene is related to the tyrosine kinase oncogenes

One FISH, two FISH, red FISH, blue FISH

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Evidence for two distinct c-src loci on human chromosomes 1 and 20

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

Correction: Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Hay in a haystack

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Therapy-related myeloid neoplasms: when genetics and environment collide

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Dissecting the role of aberrant DNA methylation in human leukaemia

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

The trend of disruption in the functional brain network topology of Alzheimer’s disease

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

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