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Showing 1–6 of 6 results
Advanced filters: Author: Michelle M. Spiering Clear advanced filters

  • Enzymes that form a metabolic pathway in which the product of one enzyme is the substrate for the next have now been shown to associate through a process of sequential, directed chemotactic movement. The extent of enzyme migration is proportional to the exposure time to the substrate gradient.

    • Xi Zhao
    • Henri Palacci
    • Ayusman Sen
    Research
    Nature Chemistry
    Volume: 10, P: 311-317

  • John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

    • Norihiro Kato
    • Marie Loh
    • John C Chambers
    Research
    Nature Genetics
    Volume: 47, P: 1282-1293

  • In this proof of principle the authors use magnetic tweezers to unzip a DNA hairpin and then measure the molecule extension during rezipping in the presence of oligomers that transiently block the rezipping process. The extent of these blockages allows them to determine the DNA sequence.

    • Fangyuan Ding
    • Maria Manosas
    • Vincent Croquette
    Research
    Nature Methods
    Volume: 9, P: 367-372

  • Structures of the clamp loader–clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

    • Zhihao Zhuang
    • Michelle M Spiering
    • Stephen J Benkovic
    News & Views
    Nature Structural & Molecular Biology
    Volume: 11, P: 580-581