The mesendoderm is located in the embryonic primitive streak's anterior region, which is specified by the transcription factor FOXH1. Here, the authors show that human fibroblasts transit through a mesendoderm-like state during reprogramming into pluripotent cells, and that expression of FOXH1 enhances reprogramming efficiency.
- Kazutoshi Takahashi
- Koji Tanabe
- Shinya Yamanaka
